Association of Key Genes IFIT1 and IFIT3 with Immune Infiltration in Systemic Lupus Erythematosus

Systemic lupus erythematosus is a diffuse connective tissue disease mediated by autoimmunity and characterized immune inflammation. The purpose of this study to explore candidate key genes cell infiltration involved in the pathogenesis systemic erythematosus. Intersection derived from differentially expressed between patients healthy individuals are identified weighted gene co-expression network analysis module were aimed for ontology functional enrichment Kyoto encyclopedia genomes pathway analysis. interferon induced protein with tetratricopeptide repeats 1 3 searched through protein-protein interaction network. cell-type identification estimating relative subsets ribonucleic acid transcripts arithmetic tool assessed abundance cells samples patients. Enzymelinked immunosorbent assay confirmed differential expression serum controls. This found that may devote development can be used as prediction target In addition, neutrophils plasma infiltrated more high 3. Interferon important predictors diagnosis treatment